DGAP-News: Eckert & Ziegler to Supply Telix with Lutetium-177 for Clinical Trials

Berlin, 9 February 2022. Eckert & Ziegler (ISIN DE0005659700, TecDAX) has executed with Telix Pharmaceuticals Limited (ASX:TLX, Telix) a comprehensive global supply agreement for Eckert & Ziegler's therapeutic radioisotope Lutetium-177 (non-carrier-added ¹⁷⁷Lu). The radiopharmaceutical will be used to advance Telix's portfolio of Molecularly Targeted Radiation (MTR) investigational products.

EZAG will immediately commence supply of n.c.a. ¹⁷⁷Lu for use in clinical trials of Telix's therapeutic candidates TLX591 (¹⁷⁷Lu-rosopatamab for advanced prostate cancer) and TLX250 (¹⁷⁷Lu-girentuximab for kidney cancer).

Lutetium-177 is used in precision oncology for targeted radionuclide therapy. The radioisotope Lutetium-177, is linked to tumor specific drugs which then incorporates the radiating element of the radioisotope into the tumor cells, while largely sparing healthy tissue.

"The agreement underlines our outstanding expertise in delivering isotopes to the pharmaceutical industry. With our production facilities in Europe, Asia and in North America, we are excellently positioned to meet the increasing demand for this isotope and related development and manufacturing services," explained Dr. Harald Hasselmann, Executive Director and responsible for the Medical segment of Eckert & Ziegler. "Our recently concluded joint venture with Atom Mines LLC provides us with excellent access to the scarce and indispensable precursor ytterbium-176, enabling us to supply lutetium-177 n.c.a. in highest purity and reliably to pharmaceutical customers worldwide."

Dr. Gabriel Liberatore, Telix Group Chief Operating Officer continued, "We are pleased to have established this agreement with EZAG, a premier supplier of high-quality medical radioisotopes, who are now part of our global network of lutetium suppliers. We are committed to working with global partners with a reputation for delivering the highest quality isotopes, and a demonstrated commitment to environmentally sustainable production technologies. Telix's relationship with EZAG is a multi-isotope partnership and we are delighted to include ¹⁷⁷Lu access as part of the supply chain."

Radiotherapeutic agents that are coupled with Lutetium-177 prior to injection are currently under late-stage clinical development for several types of cancer.

About Eckert & Ziegler.
Eckert & Ziegler Strahlen- und Medizintechnik AG with more than 900 employees is one of the world's largest providers of isotope-related components for nuclear medicine and radiation therapy. The company offers services for radiopharmaceuticals at its worldwide locations, from early development to commercialization. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDAX index of Deutsche Börse.
Contributing to saving lives.

About Telix Pharmaceuticals
Telix is a biopharmaceutical company focused on the development of diagnostic and therapeutic products using Molecularly Targeted Radiation (MTR). Telix is headquartered in Melbourne, Australia with international operations in Belgium, Japan, Switzerland and the United States. Telix is developing a portfolio of clinical-stage products that address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX).

Contact:
Eckert & Ziegler AG
Karolin Riehle, Investor Relations
Robert-Rössle-Str. 10, 13125 Berlin, Germany
Tel.: +49 (0) 30 / 94 10 84-138, [email protected], www.ezag.com
Telix Pharmaceuticals:
Dr. Stewart Holmstrom, Corporate Communications
Suite 401, 55 Flemington Road, North Melbourne, VIC 3051, Australia
[email protected], www.telixpharma.com