Axsome Therapeutics' Key Drug Candidate Whiffs in Phase 3 Trial
Axsome Therapeutics (NASDAQ: AXSM) on Monday released the data from its phase 3 trial for AXS-05 in patients suffering from treatment-resistant depression (TRD), and it was not quite what the company had hoped for. AXS-05 failed to achieve its primary endpoint in the study, although it did show efficacy in its secondary endpoint.
The study of 312 patients with confirmed TRD, all of whom had all failed two or three prior treatments for depression, compared AXS-05 to bupropion (Wellbutrin). The primary endpoint was whether the patients had significantly improved symptoms (as measured by the Montgomery-Asberg Depression Rating Scale, or MADRS) after six weeks of treatment. While those patients taking Axsome's drug did slightly better than those on bupropion, the difference was not statistically significant.
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Source Fool.com
