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ellectis is an international pharmaceutical company headquartered in Paris, France. It is focused on developing and offering immunotherapies based on gene-edited CAR-T cells (UCART). Unlike other companies in the CAR-T space, Cellectis offers allogeneic CAR-T cells, which allows it to produce an off-the-shelf alternative. The company plans to utilize its validated genome-editing technology to delete the T-cell receptor (TCR) from CAR-T cells. By deleting the TCR, the CAR-T cells are no longer able to detect "non-self", thus theoretically allowing T-cells from unrelated donors to be transplanted into recipients without the risk of graft-versus-host disease. This allogeneic cell production can be standardized and controlled, while autologous cells cannot, because they are sampled from individual patients. The company has a Phase I clinical trial using anti-CD19 CAR-T cells to treat ALL and CLL planned to start in Q2 2015.

Cellectis has two major big pharma partners - Servier Laboratories and Pfizer (NYSE:PFE), which provide clinical and regulatory expertise. Under the Pfizer collaboration announced in June 2014, Cellectis received $80M, funding for Pfizer-selected CAR-T targets, and up to $185M in milestones from eachcandidate Pfizer develops (~12 targets), and then finally, tiered royalties on any future sales. The cash and support from the Servier/Pfizer partnerships serve to buffer both financial and development risks moving forward. Cellectis currently has a market cap of $803.74M, $20.21M in cash, and a quarterly burn of $2M.

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